Adipocytes play a key role in the maintenance of metabolic health. Both excesses and deficiencies in adipose tissue led to metabolic diseases including insulin resistance and nonalcoholic fatty liver disease. Nutrient storage by adipocyte is just one of their critical functions. In contexts such as exercise, fasting and cold exposure these stored nutrients are mobilize by lipolysis to provide vital fuel. Interestingly, free fatty acids released by lipolysis drive oxidative metabolism in adipocytes promoting energy expenditure. Current work in the Reilly lab is focused on understanding the molecular pathways regulating signaling and metabolism in lipolytic adipocytes.
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The Reilly lab welcomes a diverse set of talents with an interest in adipose tissue and energy metabolism.